InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KRT19

Summary

InnateDB Protein

IDBP-49365.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KRT19

Protein Name

keratin 19

Synonyms

CK19; K19; K1CS;

Species

Homo sapiens

Ensembl Protein

ENSP00000355124

InnateDB Gene

IDBG-49363 (KRT19)

Protein Structure

UniProt Annotation

Function

Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000269PubMed:16000376}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin. {ECO:0000269PubMed:16000376, ECO:0000269PubMed:2468493, ECO:0000269PubMed:2469734}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.

Experimentally validated
Total	39 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0008307	structural constituent of muscle
GO:0032403	protein complex binding

Biological Process

GO:0016032	viral process
GO:0043627	response to estrogen
GO:0045214	sarcomere organization
GO:0060706	cell differentiation involved in embryonic placenta development

Cellular Component

GO:0005882	intermediate filament
GO:0016010	dystrophin-associated glycoprotein complex
GO:0030018	Z disc
GO:0042383	sarcolemma
GO:0043034	costamere
GO:0070062	extracellular vesicular exosome
GO:0071944	cell periphery