InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PAWR

Summary

InnateDB Protein

IDBP-49370.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PAWR

Protein Name

PRKC, apoptosis, WT1, regulator

Synonyms

Par-4; PAR4;

Species

Homo sapiens

Ensembl Protein

ENSP00000328088

InnateDB Gene

IDBG-49368 (PAWR)

Protein Structure

UniProt Annotation

Function

Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down- regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. {ECO:0000269PubMed:11585763}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity). Nuclear localization includes nucleoplasm and PML nuclear bodies. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. Expression is elevated in various neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer, Parkinson and Huntington diseases and stroke. Down-regulated in several cancers. {ECO:0000269PubMed:8943350}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	54 [view]
Protein-Protein	53 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0043522	leucine zipper domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006915	apoptotic process
GO:0008285	negative regulation of cell proliferation
GO:0030889	negative regulation of B cell proliferation
GO:0042094	interleukin-2 biosynthetic process
GO:0042130	negative regulation of T cell proliferation
GO:0042986	positive regulation of amyloid precursor protein biosynthetic process
GO:0043065	positive regulation of apoptotic process
GO:0050860	negative regulation of T cell receptor signaling pathway
GO:0051017	actin filament bundle assembly
GO:0097190	apoptotic signaling pathway