InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPP1R12A

Summary

InnateDB Protein

IDBP-49406.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP1R12A

Protein Name

protein phosphatase 1, regulatory subunit 12A

Synonyms

M130; MBS; MYPT1;

Species

Homo sapiens

Ensembl Protein

ENSP00000261207

InnateDB Gene

IDBG-49402 (PPP1R12A)

Protein Structure

UniProt Annotation

Function

Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN- dependent suppression of HIF1A activity. {ECO:0000269PubMed:18477460, ECO:0000269PubMed:19245366, ECO:0000269PubMed:20354225}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12923170, ECO:0000269PubMed:18477460}. Note=Along actomyosin filaments and stress fibers.

Disease Associations

Tissue Specificity

Expressed in striated muscles, specifically in type 2a fibers (at protein level). {ECO:0000269PubMed:20634291}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	72 [view]
Protein-Protein	69 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004857	enzyme inhibitor activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0019208	phosphatase regulator activity
GO:0019901	protein kinase binding
GO:0071889	14-3-3 protein binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006470	protein dephosphorylation
GO:0007067	mitotic nuclear division
GO:0007165	signal transduction
GO:0030155	regulation of cell adhesion
GO:0035507	regulation of myosin-light-chain-phosphatase activity
GO:0043086	negative regulation of catalytic activity
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051297	centrosome organization

Cellular Component

GO:0000776	kinetochore
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0015629	actin cytoskeleton
GO:0043292	contractile fiber
GO:0072357	PTW/PP1 phosphatase complex