InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZP1

Summary

InnateDB Protein

IDBP-49419.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZP1

Protein Name

zona pellucida glycoprotein 1 (sperm receptor)

Synonyms

HEL163; OOMD;

Species

Homo sapiens

Ensembl Protein

ENSP00000278853

InnateDB Gene

IDBG-49417 (ZP1)

Protein Structure

UniProt Annotation

Function

The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida.

Subcellular Localization

Processed zona pellucida sperm-binding protein 1: Secreted, extracellular space, extracellular matrix. Note=The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian oocyte is called zona pellucida.Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Oocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0007338	single fertilization
GO:0007339	binding of sperm to zona pellucida
GO:0032504	multicellular organism reproduction

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030141	secretory granule
GO:0031012	extracellular matrix