InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HNRNPL

Summary

InnateDB Protein

IDBP-49633.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HNRNPL

Protein Name

heterogeneous nuclear ribonucleoprotein L

Synonyms

hnRNP-L; HNRPL;

Species

Homo sapiens

Ensembl Protein

ENSP00000221419

InnateDB Gene

IDBG-49631 (HNRNPL)

Protein Structure

UniProt Annotation

Function

Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. {ECO:0000269PubMed:11809897}.

Subcellular Localization

Nucleus, nucleoplasm {ECO:0000269PubMed:17289661}. Cytoplasm {ECO:0000269PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 93 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	93 [view]
Protein-Protein	91 [view]
Protein-DNA	0
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006396	RNA processing
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0045120	pronucleus
GO:0070062	extracellular vesicular exosome