InnateDB Protein
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IDBP-4966.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC5A1
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Protein Name
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solute carrier family 5 (sodium/glucose cotransporter), member 1
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Synonyms
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D22S675; NAGT; SGLT1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000266088
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InnateDB Gene
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IDBG-4964 (SLC5A1)
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Protein Structure
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Function |
Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.
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Subcellular Localization |
Membrane; Multi-pass membrane protein.
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Disease Associations |
Congenital glucose/galactose malabsorption (GGM) [MIM:606824]: Intestinal monosaccharide transporter deficiency. It is an autosomal recessive disorder manifesting itself within the first weeks of life. It is characterized by severe diarrhea and dehydration which are usually fatal unless glucose and galactose are eliminated from the diet. {ECO:0000269PubMed:10036327, ECO:0000269PubMed:11406349, ECO:0000269PubMed:2008213, ECO:0000269PubMed:8195156}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Expressed mainly in intestine and kidney.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001734
Sodium/solute symporter
IPR019900
Sodium/solute symporter, subgroup
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PFAM |
PF00474
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P13866
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PhosphoSite |
PhosphoSite-P13866
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TrEMBL |
A4QPH0
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UniProt Splice Variant |
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Entrez Gene |
6523
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UniGene |
Hs.1964
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RefSeq |
NP_000334
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HUGO |
HGNC:11036
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OMIM |
182380
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CCDS |
CCDS13902
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HPRD |
01668
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IMGT |
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EMBL |
AK297665
AK312948
AK316184
AL022321
BC139839
CH471095
CR456579
L29328
L29329
L29330
L29331
L29332
L29333
L29334
L29335
L29336
L29337
L29338
L29339
M24847
Z74021
Z80998
Z83839
Z83849
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GenPept |
AAA60320
AAB59448
AAI39840
BAG35789
BAH12645
BAH14555
CAB06087
CAG30465
CAI18756
CAI18759
CAI19810
CAI23589
EAW60006
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