Version 5.4
Homo sapiens Protein: PGA4
Summary
InnateDB Protein IDBP-49795.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PGA4
Protein Name pepsinogen 4, group I (pepsinogen A)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000367391
InnateDB Gene IDBG-304145 (PGA4)
Protein Structure
UniProt Annotation
Function Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004190 aspartic-type endopeptidase activity
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007586 digestion
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR001461 Aspartic peptidase
IPR012848 Aspartic peptidase, N-terminal
IPR021109 Aspartic peptidase domain
PFAM PF00026
PF07966
PRINTS PR00792
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P0DJD7
PhosphoSite PhosphoSite-P0DJD7
TrEMBL F5H842
UniProt Splice Variant
Entrez Gene 643847
UniGene Hs.661883
RefSeq NP_001073276
HUGO HGNC:8886
OMIM 169720
CCDS CCDS31575
HPRD
IMGT
EMBL AK291864 AP000437 AP003037 BC150659 BC171910 BC171920 J00279 J00280 J00281 J00282 J00283 J00284 J00285 J00286 J00287
GenPept AAA98529 AAI50660 AAI71910 AAI71920 BAF84553

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca