InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SARS2

Summary

InnateDB Protein

IDBP-49811.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SARS2

Protein Name

F-box protein 17

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000221431

InnateDB Gene

IDBG-49809 (SARS2)

Protein Structure

UniProt Annotation

Function

Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Hyperuricemia pulmonary hypertension renal failure and alkalosis (HUPRA) [MIM:613845]: A multisystem disorder characterized by onset in infancy of progressive renal failure leading to electrolyte imbalances, metabolic alkalosis, pulmonary hypertension, hypotonia, and delayed development. Affected individuals are born prematurely. {ECO:0000269PubMed:21255763}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	21 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004812	aminoacyl-tRNA ligase activity
GO:0004828	serine-tRNA ligase activity
GO:0005524	ATP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006418	tRNA aminoacylation for protein translation
GO:0006434	seryl-tRNA aminoacylation
GO:0010467	gene expression
GO:0097056	selenocysteinyl-tRNA(Sec) biosynthetic process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

InterPro

IPR002314 Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain
IPR002317 Serine-tRNA ligase, type1
IPR006195 Aminoacyl-tRNA synthetase, class II
IPR010978 tRNA-binding arm

PFAM

PF00587

PRINTS

PR00981

PIRSF

PIRSF001529

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt