Homo sapiens Protein: FBXO17
Summary
InnateDB Protein IDBP-49896.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXO17
Protein Name F-box protein 17
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000292852
InnateDB Gene IDBG-728125 (FBXO17)
Protein Structure
UniProt Annotation
Function Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex- type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in heart, skeletal muscle, liver and kidney. Expressed at lower levels in spleen and brain. {ECO:0000269PubMed:12383498}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0005515 protein binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0030163 protein catabolic process
Cellular Component
GO:0019005 SCF ubiquitin ligase complex
Protein Structure and Domains
PDB ID
InterPro IPR001810 F-box domain
IPR007397 F-box associated (FBA) domain
IPR008979 Galactose-binding domain-like
PFAM PF00646
PF12937
PF13013
PF04300
PRINTS
PIRSF
SMART SM00256
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96EF6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 115290
UniGene
RefSeq NP_079183
HUGO HGNC:18754
OMIM 609094
CCDS CCDS12526
HPRD 16436
IMGT
EMBL AF386743 AK057934 BC012385
GenPept AAH12385 AAL37625 BAB71616