Homo sapiens Protein: SH3KBP1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-49944.7 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | SH3KBP1 | ||||||||||||||||||||||
Protein Name | SH3-domain kinase binding protein 1 | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000369020 | ||||||||||||||||||||||
InnateDB Gene | IDBG-49936 (SH3KBP1) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. {ECO:0000250, ECO:0000269PubMed:11894095, ECO:0000269PubMed:11894096, ECO:0000269PubMed:12177062, ECO:0000269PubMed:12734385, ECO:0000269PubMed:12771190, ECO:0000269PubMed:15090612, ECO:0000269PubMed:15707590, ECO:0000269PubMed:16177060, ECO:0000269PubMed:16256071, ECO:0000269PubMed:21834987}. | ||||||||||||||||||||||
Subcellular Localization | Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome. Cell junction, focal adhesion {ECO:0000250}. Note=Localized in endocytic vesicles containing clustered receptors. Colocalizes with ASAP1 in vesicular structures. Colocalized with actin microfilaments and focal adhesions (By similarity). Colocalized with MAGI2 in synaptosomes (By similarity). {ECO:0000250}. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Ubiquitously expressed. Also expressed in some cancer cell lines. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 306 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR001452
SH3 domain IPR011511 Variant SH3 domain IPR013315 Spectrin alpha chain, SH3 domain |
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PFAM |
PF00018
PF14604 PF07653 |
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PRINTS |
PR00452
PR01887 |
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PIRSF | |||||||||||||||||||||||
SMART |
SM00326
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q96B97 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q96B97 | ||||||||||||||||||||||
TrEMBL | B7Z6E8 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 30011 | ||||||||||||||||||||||
UniGene | Hs.726365 | ||||||||||||||||||||||
RefSeq | NP_001019837 | ||||||||||||||||||||||
HUGO | HGNC:13867 | ||||||||||||||||||||||
OMIM | 300374 | ||||||||||||||||||||||
CCDS | CCDS35213 | ||||||||||||||||||||||
HPRD | 02301 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AF230904 AF329267 AF329268 AF542051 AK293234 AK293237 AK300189 AL732325 AL732327 AL732409 AL732423 AL772197 BC015806 BC050663 | ||||||||||||||||||||||
GenPept | AAF37854 AAH15806 AAH50663 AAK95587 AAN77231 AAO13348 BAH11470 BAH11471 BAH13234 CAI40277 CAI40278 CAI40511 CAI40512 CAI41254 | ||||||||||||||||||||||