InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SIX2

Summary

InnateDB Protein

IDBP-50016.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SIX2

Protein Name

SIX homeobox 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000304502

InnateDB Gene

IDBG-50012 (SIX2)

Protein Structure

UniProt Annotation

Function

May be involved in limb tendon and ligament development. {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Strongly expressed in skeletal muscle. Expressed in Wilms' tumor and in the cap mesenchyme of fetal kidney (at protein level). {ECO:0000269PubMed:22703800}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001656	metanephros development
GO:0001822	kidney development
GO:0002062	chondrocyte differentiation
GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0006606	protein import into nucleus
GO:0007501	mesodermal cell fate specification
GO:0008283	cell proliferation
GO:0009653	anatomical structure morphogenesis
GO:0042474	middle ear morphogenesis
GO:0045596	negative regulation of cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0048704	embryonic skeletal system morphogenesis