Version 5.4
Homo sapiens Protein: ACTR3B
Summary
InnateDB Protein IDBP-50056.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACTR3B
Protein Name ARP3 actin-related protein 3 homolog B (yeast)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000367007
InnateDB Gene IDBG-50050 (ACTR3B)
Protein Structure
UniProt Annotation
Function Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors. {ECO:0000269PubMed:14651955}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection {ECO:0000250}.
Disease Associations
Tissue Specificity Detected in fetal brain. Detected throughout the adult brain, in neurons from gray matter, but not in white matter. Detected in liver, skeletal muscle and pancreas. Detected in lung adenocarcinoma cells with low metastatic potential, but not in lung adenocarcinoma cells with high metastatic potential. {ECO:0000269PubMed:10806390, ECO:0000269PubMed:11162478}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003779 actin binding
GO:0005524 ATP binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0042995 cell projection
Protein Structure and Domains
PDB ID
InterPro IPR004000 Actin-related protein
PFAM PF00022
PRINTS PR00190
PIRSF
SMART SM00268
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P1U1
PhosphoSite PhosphoSite-Q9P1U1
TrEMBL C9J580
UniProt Splice Variant
Entrez Gene 57180
UniGene Hs.647117
RefSeq NP_001035225
HUGO HGNC:17256
OMIM
CCDS CCDS34782
HPRD 12489
IMGT
EMBL AC005586 AC006008 AC072057 AC092180 AF023453 AF086920 AK294292 AK315534 BC008682 BC015207
GenPept AAC98904 AAH08682 AAH15207 AAP97150 BAG37914 BAG57575

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca