InnateDB Protein
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IDBP-5008.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CNDP2
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Protein Name
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CNDP dipeptidase 2 (metallopeptidase M20 family)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000325548
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InnateDB Gene
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IDBG-5004 (CNDP2)
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Protein Structure
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Function |
Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. {ECO:0000269PubMed:17121880, ECO:0000269PubMed:19346245}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:12473676, ECO:0000269PubMed:17121880}.
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Disease Associations |
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Tissue Specificity |
Isoform 1 is ubiquitously expressed with higher levels in kidney and liver (at protein level). Isoform 2 is expressed in fetal tissues, it is only expressed in adult liver and placental tissues. {ECO:0000269PubMed:12473676, ECO:0000269PubMed:17121880}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
39
[view]
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Protein-Protein |
37
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002933
Peptidase M20
IPR011650
Peptidase M20, dimerisation domain
IPR017153
Glutathione degradosome, DUG1
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PFAM |
PF01546
PF07687
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PRINTS |
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PIRSF |
PIRSF037242
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96KP4
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PhosphoSite |
PhosphoSite-Q96KP4
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TrEMBL |
V9HWE5
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UniProt Splice Variant |
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Entrez Gene |
55748
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UniGene |
Hs.711198
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RefSeq |
NP_060705
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HUGO |
HGNC:24437
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OMIM |
169800
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CCDS |
CCDS12006
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HPRD |
09893
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IMGT |
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EMBL |
AC009704
AF258592
AJ347717
AK001262
AK001692
AK097155
AK300904
AX523938
BC001375
BC003176
CH471117
EU794600
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GenPept |
AAG23795
AAH01375
AAH03176
ACJ13654
BAA91587
BAA91840
BAG53426
BAG62540
CAC69883
CAD56843
EAW66551
EAW66552
EAW66554
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