InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KAT2A

Summary

InnateDB Protein

IDBP-50289.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KAT2A

Protein Name

K(lysine) acetyltransferase 2A

Synonyms

GCN5; GCN5L2; hGCN5; PCAF-b;

Species

Homo sapiens

Ensembl Protein

ENSP00000225916

InnateDB Gene

IDBG-50287 (KAT2A)

Protein Structure

UniProt Annotation

Function

Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269PubMed:19103755}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11564863}.

Disease Associations

Tissue Specificity

Expressed in all tissues tested, with most abundant expression in ovary.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 150 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	150 [view]
Protein-Protein	149 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding
GO:0008080	N-acetyltransferase activity
GO:0010484	H3 histone acetyltransferase activity
GO:0042826	histone deacetylase binding
GO:0043997	histone acetyltransferase activity (H4-K12 specific)

Biological Process

GO:0001701	in utero embryonic development
GO:0001756	somitogenesis
GO:0001843	neural tube closure
GO:0006325	chromatin organization
GO:0006338	chromatin remodeling
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007399	nervous system development
GO:0008283	cell proliferation
GO:0016032	viral process
GO:0016573	histone acetylation
GO:0016578	histone deubiquitination
GO:0021537	telencephalon development
GO:0022037	metencephalon development
GO:0030901	midbrain development
GO:0031647	regulation of protein stability
GO:0035264	multicellular organism growth
GO:0043966	histone H3 acetylation
GO:0043983	histone H4-K12 acetylation
GO:0044154	histone H3-K14 acetylation
GO:0045722	positive regulation of gluconeogenesis

Cellular Component

GO:0000123	histone acetyltransferase complex
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex
GO:0030914	STAGA complex
GO:0033276	transcription factor TFTC complex
GO:0072686	mitotic spindle