InnateDB Protein
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IDBP-50321.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TAF7
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Protein Name
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TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
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Synonyms
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TAF2F; TAFII55;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000312709
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InnateDB Gene
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IDBG-50319 (TAF7)
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Protein Structure
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Function |
Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively).
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
Ubiquitous.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
55
[view]
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Protein-Protein |
51
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0000296
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spermine transport
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GO:0006352
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DNA-templated transcription, initiation
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0006367
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transcription initiation from RNA polymerase II promoter
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GO:0006469
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negative regulation of protein kinase activity
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GO:0030520
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intracellular estrogen receptor signaling pathway
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GO:0035067
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negative regulation of histone acetylation
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GO:0045892
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negative regulation of transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
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InterPro |
IPR006751
TAFII55 protein, conserved region
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PFAM |
PF04658
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q15545
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PhosphoSite |
PhosphoSite-Q15545
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
6879
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UniGene |
Hs.438838
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RefSeq |
NP_005633
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HUGO |
HGNC:11541
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OMIM |
600573
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CCDS |
CCDS4259
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HPRD |
07196
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IMGT |
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EMBL |
AF349038
AK314837
BC032737
CH471062
U18062
X97999
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GenPept |
AAB60347
AAH32737
AAK30585
BAG37356
CAA66636
EAW61966
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