Version 5.4
Homo sapiens Protein: RAB3IL1
Summary
InnateDB Protein IDBP-50652.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAB3IL1
Protein Name RAB3A interacting protein (rabin3)-like 1
Synonyms GRAB;
Species Homo sapiens
Ensembl Protein ENSP00000301773
InnateDB Gene IDBG-50650 (RAB3IL1)
Protein Structure
UniProt Annotation
Function Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B. {ECO:0000269PubMed:20937701}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017112 Rab guanyl-nucleotide exchange factor activity
Biological Process
GO:0015031 protein transport
GO:0032851 positive regulation of Rab GTPase activity
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR009449 GDPGTP exchange factor Sec2p
PFAM PF06428
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TBN0
PhosphoSite PhosphoSite-Q8TBN0
TrEMBL
UniProt Splice Variant
Entrez Gene 5866
UniGene Hs.13759
RefSeq NP_001258615
HUGO HGNC:9780
OMIM
CCDS CCDS60809
HPRD 10181
IMGT
EMBL AF084557 BC022239 BC051820
GenPept AAF28399 AAH22239 AAH51820

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca