Version 5.4
Homo sapiens Protein: EID2
Summary
InnateDB Protein IDBP-50689.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EID2
Protein Name EP300 interacting inhibitor of differentiation 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000375073
InnateDB Gene IDBG-50685 (EID2)
Protein Structure
UniProt Annotation
Function Interacts with EP300 and acts as a repressor of MYOD- dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex. {ECO:0000269PubMed:12586827, ECO:0000269PubMed:14585496, ECO:0000269PubMed:14612439}.
Subcellular Localization Nucleus {ECO:0000269PubMed:14585496}.
Disease Associations
Tissue Specificity Most abundantly expressed in placenta. Highly expressed in liver, brain, heart, skeletal muscle, and kidney. {ECO:0000269PubMed:14585496}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046332 SMAD binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0007181 transforming growth factor beta receptor complex assembly
GO:0007183 SMAD protein complex assembly
GO:0007517 muscle organ development
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0030154 cell differentiation
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0042127 regulation of cell proliferation
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N6I1
PhosphoSite PhosphoSite-Q8N6I1
TrEMBL
UniProt Splice Variant
Entrez Gene 163126
UniGene Hs.605198
RefSeq NP_694964
HUGO HGNC:28292
OMIM 609773
CCDS CCDS12540
HPRD 16754
IMGT
EMBL AK128468 AY251272 BC030137 BC099899 CH471126
GenPept AAH30137 AAH99899 AAP12559 BAC87454 EAW56909

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca