InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STAT3

Summary

InnateDB Protein

IDBP-50712.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STAT3

Protein Name

signal transducer and activator of transcription 3 (acute-phase response factor)

Synonyms

ADMIO; APRF; HIES;

Species

Homo sapiens

Ensembl Protein

ENSP00000373923

InnateDB Gene

IDBG-50702 (STAT3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 340 experimentally validated interaction(s) in this database.
They are also associated with 144 interaction(s) predicted by orthology.

Experimentally validated
Total	340 [view]
Protein-Protein	285 [view]
Protein-DNA	53 [view]
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	144 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000980 SH2 domain
IPR008967 p53-like transcription factor, DNA-binding
IPR013800 STAT transcription factor, all-alpha
IPR013801 STAT transcription factor, DNA-binding
IPR015988 STAT transcription factor, coiled coil

PFAM

PF00017
PF14633
PF01017
PF02864

PRINTS

PR00401

PIRSF

SMART

SM00252

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt