InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHRNA7

Summary

InnateDB Protein

IDBP-5072.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHRNA7

Protein Name

cholinergic receptor, nicotinic, alpha 7

Synonyms

CHRNA7-2; NACHRA7;

Species

Homo sapiens

Ensembl Protein

ENSP00000303727

InnateDB Gene

IDBG-5070 (CHRNA7)

Protein Structure

UniProt Annotation

Function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

Subcellular Localization

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0004889	acetylcholine-activated cation-selective channel activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0015464	acetylcholine receptor activity
GO:0015643	toxic substance binding
GO:0017081	chloride channel regulator activity
GO:0022848	acetylcholine-gated cation channel activity
GO:0042166	acetylcholine binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000187	activation of MAPK activity
GO:0001666	response to hypoxia
GO:0006810	transport
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0007613	memory
GO:0008284	positive regulation of cell proliferation
GO:0032720	negative regulation of tumor necrosis factor production
GO:0034220	ion transmembrane transport
GO:0035094	response to nicotine
GO:0045766	positive regulation of angiogenesis
GO:0050890	cognition

Cellular Component

GO:0005886	plasma membrane
GO:0005892	acetylcholine-gated channel complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002394 Nicotinic acetylcholine receptor
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding

PFAM

PF02932
PF02931

PRINTS

PR00254
PR00252

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P36544