InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HDAC3

Summary

InnateDB Protein

IDBP-50727.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HDAC3

Protein Name

histone deacetylase 3

Synonyms

HD3; RPD3; RPD3-2;

Species

Homo sapiens

Ensembl Protein

ENSP00000302967

InnateDB Gene

IDBG-50725 (HDAC3)

Protein Structure

UniProt Annotation

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys- 27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation. {ECO:0000269PubMed:21444723, ECO:0000269PubMed:23911289}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 365 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	365 [view]
Protein-Protein	282 [view]
Protein-DNA	16 [view]
Protein-RNA	0
DNA-DNA	67 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003714	transcription corepressor activity
GO:0004407	histone deacetylase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019899	enzyme binding
GO:0030332	cyclin binding
GO:0031490	chromatin DNA binding
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033558	protein deacetylase activity
GO:0042826	histone deacetylase binding
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006476	protein deacetylation
GO:0007219	Notch signaling pathway
GO:0007346	regulation of mitotic cell cycle
GO:0016568	chromatin modification
GO:0016575	histone deacetylation
GO:0032922	circadian regulation of gene expression
GO:0040014	regulation of multicellular organism growth
GO:0043066	negative regulation of apoptotic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045786	negative regulation of cell cycle
GO:0045892	negative regulation of transcription, DNA-templated
GO:0046329	negative regulation of JNK cascade
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051225	spindle assembly
GO:0070932	histone H3 deacetylation
GO:0070933	histone H4 deacetylation

Cellular Component

GO:0000118	histone deacetylase complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005876	spindle microtubule
GO:0017053	transcriptional repressor complex