InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MNX1

Summary

InnateDB Protein

IDBP-50745.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MNX1

Protein Name

motor neuron and pancreas homeobox 1

Synonyms

HB9; HLXB9; HOXHB9; SCRA1;

Species

Homo sapiens

Ensembl Protein

ENSP00000252971

InnateDB Gene

IDBG-50743 (MNX1)

Protein Structure

UniProt Annotation

Function

Putative transcription factor involved in pancreas development and function.

Subcellular Localization

Nucleus.

Disease Associations

Currarino syndrome (CURRAS) [MIM:176450]: The triad of a presacral tumor, sacral agenesis and anorectal malformation constitutes the Currarino syndrome which is caused by dorsal- ventral patterning defects during embryonic development. The syndrome occurs in the majority of patients as an autosomal dominant trait. {ECO:0000269PubMed:10631160, ECO:0000269PubMed:10749657, ECO:0000269PubMed:19853743, ECO:0000269PubMed:22820079}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in lymphoid and pancreatic tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001764	neuron migration
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006959	humoral immune response
GO:0008045	motor neuron axon guidance
GO:0009653	anatomical structure morphogenesis
GO:0009791	post-embryonic development
GO:0021520	spinal cord motor neuron cell fate specification
GO:0021675	nerve development
GO:0021904	dorsal/ventral neural tube patterning
GO:0021953	central nervous system neuron differentiation
GO:0030182	neuron differentiation
GO:0031016	pancreas development
GO:0031018	endocrine pancreas development
GO:0048667	cell morphogenesis involved in neuron differentiation
GO:0048812	neuron projection morphogenesis
GO:0060539	diaphragm development
GO:0060541	respiratory system development