Version 5.4
Homo sapiens Protein: INCENP
Summary
InnateDB Protein IDBP-50808.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INCENP
Protein Name inner centromere protein antigens 135/155kDa
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000278849
InnateDB Gene IDBG-50806 (INCENP)
Protein Structure
UniProt Annotation
Function Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts through association with AURKB or AURKC. Seems to bind directly to microtubules. Controls the kinetochore localization of BUB1. {ECO:0000269PubMed:12925766, ECO:0000269PubMed:15316025, ECO:0000269PubMed:16760428}.
Subcellular Localization Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to inner kinetochore. Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with AURKB at mitotic chromosomes.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
Experimentally validated
Total 38 [view]
Protein-Protein 35 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0000910 cytokinesis
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0005721 centromeric heterochromatin
GO:0005819 spindle
GO:0005829 cytosol
GO:0005874 microtubule
GO:0043234 protein complex
Protein Structure and Domains
PDB ID
InterPro IPR005635 Inner centromere protein, ARK-binding domain
IPR022006 Chromosome passenger complex (CPC) protein INCENP N-terminal
PFAM PF03941
PF12178
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NQS7
PhosphoSite PhosphoSite-Q9NQS7
TrEMBL E9PM67
UniProt Splice Variant
Entrez Gene 3619
UniGene Hs.142179
RefSeq NP_064623
HUGO HGNC:6058
OMIM 604411
CCDS CCDS31582
HPRD 05103
IMGT
EMBL AF282265 AP002793 AY714053 BC098576 CH471076
GenPept AAF87584 AAH98576 AAU04398 EAW74004

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca