InnateDB Protein
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IDBP-51113.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MLX
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Protein Name
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MAX-like protein X
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Synonyms
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bHLHd13; MAD7; MXD7; TCFL4;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000320913
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InnateDB Gene
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IDBG-51109 (MLX)
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Protein Structure
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Function |
Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. {ECO:0000269PubMed:10593926, ECO:0000269PubMed:12446771, ECO:0000269PubMed:16782875}.
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Subcellular Localization |
Isoform Alpha: Cytoplasm. Note=Found predominantly in the cytoplasm.Isoform Beta: Cytoplasm. Note=Found predominantly in the cytoplasm.Isoform Gamma: Nucleus. Note=Found predominantly in the nucleus.
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Disease Associations |
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Tissue Specificity |
Expressed in all tissues tested, including spleen, thymus, prostate, ovary, intestine, colon, peripheral blood leukocyte, heart, liver, skeletal muscle and kidney. Lower levels of expression in testis, brain, placenta and lung. {ECO:0000269PubMed:10593926}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
22
[view]
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Protein-Protein |
20
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000977
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RNA polymerase II regulatory region sequence-specific DNA binding
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GO:0001227
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RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
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GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0008134
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transcription factor binding
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GO:0042803
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protein homodimerization activity
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GO:0046982
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protein heterodimerization activity
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GO:0046983
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protein dimerization activity
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006112
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energy reserve metabolic process
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GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0031325
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positive regulation of cellular metabolic process
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GO:0044281
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small molecule metabolic process
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GO:0045892
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negative regulation of transcription, DNA-templated
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Cellular Component |
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PDB ID |
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InterPro |
IPR011598
Myc-type, basic helix-loop-helix (bHLH) domain
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PFAM |
PF00010
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PRINTS |
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PIRSF |
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SMART |
SM00353
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UH92
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PhosphoSite |
PhosphoSite-Q9UH92
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
6945
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UniGene |
Hs.732454
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RefSeq |
NP_937848
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HUGO |
HGNC:11645
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OMIM |
602976
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CCDS |
CCDS42341
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HPRD |
04278
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IMGT |
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EMBL |
AF203978
AF213666
AF213667
AF213668
AK000150
AK290258
AK314378
AK315432
BC010689
BT009812
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GenPept |
AAF14638
AAG40145
AAG40146
AAG40147
AAH10689
AAP88814
BAA90977
BAF82947
BAG37005
BAG37820
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