InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGEF7

Summary

InnateDB Protein

IDBP-51174.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGEF7

Protein Name

Rho guanine nucleotide exchange factor (GEF) 7

Synonyms

BETA-PIX; COOL-1; COOL1; Nbla10314; P50; P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB;

Species

Homo sapiens

Ensembl Protein

ENSP00000364875

InnateDB Gene

IDBG-51160 (ARHGEF7)

Protein Structure

UniProt Annotation

Function

Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. {ECO:0000250, ECO:0000269PubMed:18184567, ECO:0000269PubMed:18716323, ECO:0000269PubMed:19041750}.

Subcellular Localization

Cell junction, focal adhesion {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Note=Detected at cell adhesions. A small proportion is detected at focal adhesions.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	65 [view]
Protein-Protein	62 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0007399	nervous system development
GO:0030032	lamellipodium assembly
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0043065	positive regulation of apoptotic process
GO:0043547	positive regulation of GTPase activity
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0001726	ruffle
GO:0005829	cytosol
GO:0005925	focal adhesion
GO:0005938	cell cortex
GO:0030027	lamellipodium
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043234	protein complex