InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAP3K10

Summary

InnateDB Protein

IDBP-51214.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP3K10

Protein Name

mitogen-activated protein kinase kinase kinase 10

Synonyms

MEKK10; MLK2; MST;

Species

Homo sapiens

Ensembl Protein

ENSP00000253055

InnateDB Gene

IDBG-51212 (MAP3K10)

Protein Structure

UniProt Annotation

Function

Activates the JUN N-terminal pathway. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in brain and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.

Experimentally validated
Total	33 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004706	JUN kinase kinase kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042803	protein homodimerization activity
GO:0043425	bHLH transcription factor binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007224	smoothened signaling pathway
GO:0007254	JNK cascade
GO:0007256	activation of JNKK activity
GO:0007257	activation of JUN kinase activity
GO:0008219	cell death
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0043065	positive regulation of apoptotic process
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043507	positive regulation of JUN kinase activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0046330	positive regulation of JNK cascade
GO:0046777	protein autophosphorylation

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011511 Variant SH3 domain
IPR016231 Mitogen-activated protein (MAP) kinase kinase kinase, 9/10/11
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00018
PF14604
PF07653

PRINTS

PR00109
PR00452

PIRSF

PIRSF000556

SMART

SM00326
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References