InnateDB Protein
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IDBP-51245.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FGF1
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Protein Name
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fibroblast growth factor 1 (acidic)
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Synonyms
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AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1; FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000352329
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InnateDB Gene
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IDBG-51235 (FGF1)
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Protein Structure
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Function |
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. {ECO:0000269PubMed:16597617, ECO:0000269PubMed:20145243, ECO:0000269PubMed:8663044}.
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Subcellular Localization |
Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle. {ECO:0000269PubMed:11964394, ECO:0000269PubMed:7504343}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
27
[view]
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Protein-Protein |
26
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0001525
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angiogenesis
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GO:0007165
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signal transduction
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GO:0007173
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epidermal growth factor receptor signaling pathway
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GO:0007275
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multicellular organismal development
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GO:0008284
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positive regulation of cell proliferation
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GO:0008286
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insulin receptor signaling pathway
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GO:0008543
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fibroblast growth factor receptor signaling pathway
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GO:0009653
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anatomical structure morphogenesis
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GO:0030335
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positive regulation of cell migration
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GO:0034605
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cellular response to heat
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GO:0038095
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Fc-epsilon receptor signaling pathway
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GO:0045087
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innate immune response
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GO:0045542
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positive regulation of cholesterol biosynthetic process
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GO:0045766
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positive regulation of angiogenesis
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0048011
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neurotrophin TRK receptor signaling pathway
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GO:0048015
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phosphatidylinositol-mediated signaling
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GO:0051781
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positive regulation of cell division
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GO:0060681
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branch elongation involved in ureteric bud branching
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GO:0072163
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mesonephric epithelium development
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GO:1902533
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positive regulation of intracellular signal transduction
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Cellular Component |
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PDB ID |
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InterPro |
IPR002209
Fibroblast growth factor family
IPR008996
Cytokine, IL-1-like
IPR028142
IL-1 family/FGF family
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PFAM |
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PRINTS |
PR00263
PR00262
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PIRSF |
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SMART |
SM00442
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TIGRFAMs |
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Modification |
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SwissProt |
P05230
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PhosphoSite |
PhosphoSite-P05230
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TrEMBL |
Q9UBK1
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UniProt Splice Variant |
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Entrez Gene |
2246
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UniGene |
Hs.742465
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RefSeq |
NP_001244141
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HUGO |
HGNC:3665
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OMIM |
131220
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CCDS |
CCDS4275
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HPRD |
00567
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IMGT |
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EMBL |
AC005370
AC005592
AK289762
AK312301
AY601819
BC032697
CH471062
L01485
L01487
M13361
M23086
M23087
M30490
M30491
M30492
M60515
M60516
S67291
S67292
X51943
X59065
X65778
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GenPept |
AAA51672
AAA51673
AAA52425
AAA52446
AAA52447
AAA52638
AAA79245
AAB29057
AAB29058
AAH32697
AAS99352
BAF82451
BAG35227
CAA36206
CAA41788
CAA46661
EAW61881
EAW61882
EAW61885
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