Homo sapiens Protein: PSIP1 | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-51341.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | PSIP1 | ||||||||||||||||||||||
Protein Name | PC4 and SFRS1 interacting protein 1 | ||||||||||||||||||||||
Synonyms | DFS70; LEDGF; p52; p75; PAIP; PSIP2; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000370109 | ||||||||||||||||||||||
InnateDB Gene | IDBG-51337 (PSIP1) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269PubMed:15642333}. | ||||||||||||||||||||||
Subcellular Localization | Nucleus {ECO:0000269PubMed:15642333, ECO:0000269PubMed:9885563}. Note=Remains chromatin-associated throughout the cell cycle. | ||||||||||||||||||||||
Disease Associations | Note=A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4. | ||||||||||||||||||||||
Tissue Specificity | Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions. {ECO:0000269PubMed:15642333, ECO:0000269PubMed:9822615}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
|
||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||
Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR000313
PWWP domain IPR017859 Treacle-like, Treacher Collins Syndrome IPR021567 Lens epithelium-derived growth factor (LEDGF) |
||||||||||||||||||||||
PFAM |
PF00855
PF11467 |
||||||||||||||||||||||
PRINTS |
PR01503
|
||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||
SMART |
SM00293
|
||||||||||||||||||||||
TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | O75475 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-O75475 | ||||||||||||||||||||||
TrEMBL | Q8N4N4 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 11168 | ||||||||||||||||||||||
UniGene | Hs.575668 | ||||||||||||||||||||||
RefSeq | XP_005251412 | ||||||||||||||||||||||
HUGO | HGNC:9527 | ||||||||||||||||||||||
OMIM | 603620 | ||||||||||||||||||||||
CCDS | CCDS6479 | ||||||||||||||||||||||
HPRD | 04688 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AF063020 AF098482 AF098483 AF199339 AF432220 AL359998 AL441925 AL513423 BC033817 BC044568 BC064135 CH471071 U94319 | ||||||||||||||||||||||
GenPept | AAB52589 AAC25167 AAC97945 AAC97946 AAF25870 AAF25871 AAH33817 AAH44568 AAH64135 AAL99926 CAH71355 CAI13287 EAW58675 EAW58677 EAW58678 EAW58679 | ||||||||||||||||||||||