InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GANAB

Summary

InnateDB Protein

IDBP-51373.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GANAB

Protein Name

glucosidase, alpha; neutral AB

Synonyms

G2AN; GLUII;

Species

Homo sapiens

Ensembl Protein

ENSP00000340466

InnateDB Gene

IDBG-51371 (GANAB)

Protein Structure

UniProt Annotation

Function

Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. {ECO:0000269PubMed:10929008}.

Subcellular Localization

Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}. Melanosome {ECO:0000269PubMed:10929008, ECO:0000269PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Disease Associations

Tissue Specificity

Detected in placenta. {ECO:0000269PubMed:3881423}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	67 [view]
Protein-Protein	67 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0005515	protein binding
GO:0030246	carbohydrate binding
GO:0033919	glucan 1,3-alpha-glucosidase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006457	protein folding
GO:0018279	protein N-linked glycosylation via asparagine
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005788	endoplasmic reticulum lumen
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0017177	glucosidase II complex
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome