Homo sapiens Protein: PLXNC1
Summary
InnateDB Protein IDBP-51380.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLXNC1
Protein Name plexin C1
Synonyms CD232; PLXN-C1; VESPR;
Species Homo sapiens
Ensembl Protein ENSP00000258526
InnateDB Gene IDBG-51378 (PLXNC1)
Protein Structure
UniProt Annotation
Function Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Detected in heart, brain, lung, spleen and placenta. {ECO:0000269PubMed:9586637}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007275 multicellular organismal development
GO:0007411 axon guidance
Cellular Component
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001627 Sema domain
IPR002165 Plexin
IPR002909 IPT domain
IPR008936 Rho GTPase activation protein
IPR013548 Plexin, cytoplasmic RasGAP domain
IPR014756 Immunoglobulin E-set
IPR016201 Plexin-like fold
PFAM PF01403
PF01437
PF01833
PF08337
PRINTS
PIRSF
SMART SM00630
SM00429
SM00423
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O60486
PhosphoSite PhosphoSite-O60486
TrEMBL F8VUW4
UniProt Splice Variant
Entrez Gene 10154
UniGene Hs.584845
RefSeq NP_005752
HUGO HGNC:9106
OMIM 604259
CCDS CCDS9049
HPRD 05036
IMGT
EMBL AB208934 AC073655 AC123567 AF030339
GenPept AAC18823 BAD92171