InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SOX1

Summary

InnateDB Protein

IDBP-51538.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SOX1

Protein Name

SRY (sex determining region Y)-box 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000330218

InnateDB Gene

IDBG-51536 (SOX1)

Protein Structure

UniProt Annotation

Function

Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Mainly expressed in the developing central nervous system.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001046	core promoter sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001764	neuron migration
GO:0002089	lens morphogenesis in camera-type eye
GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0021521	ventral spinal cord interneuron specification
GO:0021879	forebrain neuron differentiation
GO:0021884	forebrain neuron development
GO:0030900	forebrain development