InnateDB Protein
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IDBP-51697.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ERLEC1
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Protein Name
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endoplasmic reticulum lectin 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000367485
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InnateDB Gene
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IDBG-51695 (ERLEC1)
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Protein Structure
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Function |
Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins. {ECO:0000269PubMed:16531414, ECO:0000269PubMed:18264092, ECO:0000269PubMed:18502753}.
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Subcellular Localization |
Endoplasmic reticulum lumen {ECO:0000269PubMed:16531414, ECO:0000269PubMed:18502753}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
15
[view]
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Protein-Protein |
15
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0030433
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ER-associated ubiquitin-dependent protein catabolic process
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Cellular Component |
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PDB ID |
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InterPro |
IPR009011
Mannose-6-phosphate receptor binding domain
IPR012913
Glucosidase II beta subunit-like
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PFAM |
PF07915
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96DZ1
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PhosphoSite |
PhosphoSite-Q96DZ1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
27248
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UniGene |
Hs.438336
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RefSeq |
NP_001120870
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HUGO |
HGNC:25222
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OMIM |
611229
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CCDS |
CCDS46284
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HPRD |
10310
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IMGT |
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EMBL |
AC007883
AF131743
AF131849
AK001913
AK315477
AY358717
AY453410
BC013129
BC022228
CH471053
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GenPept |
AAD20029
AAD20060
AAH13129
AAH22228
AAQ89079
AAR26725
AAY24352
BAA91974
BAG37861
EAX00164
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