InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SSTR1

Summary

InnateDB Protein

IDBP-5174.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SSTR1

Protein Name

somatostatin receptor 1

Synonyms

SRIF-2; SS-1-R; SS1-R; SS1R;

Species

Homo sapiens

Ensembl Protein

ENSP00000267377

InnateDB Gene

IDBG-5172 (SSTR1)

Protein Structure

UniProt Annotation

Function

Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004994	somatostatin receptor activity
GO:0005515	protein binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007215	glutamate receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007267	cell-cell signaling
GO:0007283	spermatogenesis
GO:0007584	response to nutrient
GO:0007586	digestion
GO:0008285	negative regulation of cell proliferation
GO:0021549	cerebellum development
GO:0030900	forebrain development
GO:0042594	response to starvation
GO:0071392	cellular response to estradiol stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000586 Somatostatin receptor family
IPR000611 Neuropeptide Y receptor family
IPR001116 Somatostatin receptor 1
IPR001418 Opioid receptor
IPR009150 Neuropeptide B/W receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019426 7TM GPCR, serpentine receptor class v (Srv)
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10323
PF10328

PRINTS

PR00237
PR00246
PR01012
PR00587
PR00384
PR01855

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P30872