InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NDUFB4

Summary

InnateDB Protein

IDBP-51808.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NDUFB4

Protein Name

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa

Synonyms

B15; CI-B15;

Species

Homo sapiens

Ensembl Protein

ENSP00000184266

InnateDB Gene

IDBG-51806 (NDUFB4)

Protein Structure

UniProt Annotation

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Subcellular Localization

Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	12 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008137	NADH dehydrogenase (ubiquinone) activity

Biological Process

GO:0006120	mitochondrial electron transport, NADH to ubiquinone
GO:0006979	response to oxidative stress
GO:0022904	respiratory electron transport chain
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005747	mitochondrial respiratory chain complex I
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane
GO:0070062	extracellular vesicular exosome