InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SNRPF

Summary

InnateDB Protein

IDBP-51826.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNRPF

Protein Name

small nuclear ribonucleoprotein polypeptide F

Synonyms

Sm-F; SMF; snRNP-F;

Species

Homo sapiens

Ensembl Protein

ENSP00000266735

InnateDB Gene

IDBG-51824 (SNRPF)

Protein Structure

UniProt Annotation

Function

Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing. {ECO:0000269PubMed:18984161, ECO:0000269PubMed:23333303}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:18984161}. Nucleus {ECO:0000269PubMed:18984161}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.

Experimentally validated
Total	86 [view]
Protein-Protein	83 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding

Biological Process

GO:0000387	spliceosomal snRNP assembly
GO:0000398	mRNA splicing, via spliceosome
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006396	RNA processing
GO:0008334	histone mRNA metabolic process
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0031124	mRNA 3'-end processing
GO:0034660	ncRNA metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0005683	U7 snRNP
GO:0005685	U1 snRNP
GO:0005687	U4 snRNP
GO:0005689	U12-type spliceosomal complex
GO:0005829	cytosol
GO:0030532	small nuclear ribonucleoprotein complex
GO:0034709	methylosome
GO:0034715	pICln-Sm protein complex
GO:0034719	SMN-Sm protein complex
GO:0071013	catalytic step 2 spliceosome

Protein Structure and Domains

PDB ID

InterPro

IPR001163 Ribonucleoprotein LSM domain
IPR006649 Ribonucleoprotein LSM domain, eukaryotic/archaea-type
IPR010920 Like-Sm (LSM) domain
IPR016487 Small nuclear ribonucleoprotein SmF

PFAM

PF01423

PRINTS

PIRSF

PIRSF006609

SMART

SM00651

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt