InnateDB Protein
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IDBP-51905.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HAL
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Protein Name
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histidine ammonia-lyase
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Synonyms
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HIS; HSTD;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000261208
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InnateDB Gene
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IDBG-51903 (HAL)
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Protein Structure
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Function |
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Subcellular Localization |
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Disease Associations |
Histidinemia (HISTID) [MIM:235800]: Autosomal recessive disease characterized by increased histidine and histamine as well as decreased urocanic acid in body fluids. {ECO:0000269PubMed:15806399}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
|
Protein-Protein |
3
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0006548
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histidine catabolic process
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GO:0009058
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biosynthetic process
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GO:0019556
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histidine catabolic process to glutamate and formamide
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GO:0019557
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histidine catabolic process to glutamate and formate
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GO:0034641
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cellular nitrogen compound metabolic process
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GO:0044281
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small molecule metabolic process
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Cellular Component |
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PDB ID |
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InterPro |
IPR001106
Aromatic amino acid lyase
IPR005921
Histidine ammonia-lyase
IPR008948
L-Aspartase-like
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PFAM |
PF00221
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P42357
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PhosphoSite |
PhosphoSite-P42357
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TrEMBL |
Q2PH61
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UniProt Splice Variant |
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Entrez Gene |
3034
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UniGene |
Hs.742210
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RefSeq |
NP_002099
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HUGO |
HGNC:4806
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OMIM |
609457
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CCDS |
CCDS9058
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HPRD |
07187
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IMGT |
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EMBL |
AB042217
AB191160
AB191161
AB191162
AB191166
AC007298
AC126174
AK298736
AK303544
BC096097
BC096098
BC096099
CH471054
D16626
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GenPept |
AAH96097
AAH96098
AAH96099
BAA04047
BAB61863
BAE72109
BAE72110
BAE72111
BAE72115
BAG60883
BAG64570
EAW97556
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