InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POLQ

Summary

InnateDB Protein

IDBP-51982.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POLQ

Protein Name

polymerase (DNA directed), theta

Synonyms

POLH; PRO0327;

Species

Homo sapiens

Ensembl Protein

ENSP00000264233

InnateDB Gene

IDBG-51980 (POLQ)

Protein Structure

UniProt Annotation

Function

Has a DNA polymerase activity on nicked double-stranded DNA and on a singly primed DNA template. The enzyme activity is resistant to aphidicolin, and inhibited by dideoxynucleotides. Exhibites a single-stranded DNA-dependent ATPase activity. Could be involved in the repair of interstrand cross-links. {ECO:0000269PubMed:14576298}.

Subcellular Localization

Disease Associations

Tissue Specificity

Highly expressed in testis. {ECO:0000269PubMed:14576298}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0004386	helicase activity
GO:0005524	ATP binding
GO:0043142	single-stranded DNA-dependent ATPase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006260	DNA replication
GO:0006261	DNA-dependent DNA replication
GO:0006281	DNA repair

Cellular Component

GO:0005654

nucleoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001098 DNA-directed DNA polymerase, family A, palm domain
IPR001650 Helicase, C-terminal
IPR002298 DNA polymerase A
IPR011545 DEAD/DEAH box helicase domain
IPR012337 Ribonuclease H-like domain
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00476
PF00271
PF00270

PRINTS

PR00868

PIRSF

SMART

SM00482
SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt