Version 5.4
Homo sapiens Protein: ADCK4
Summary
InnateDB Protein IDBP-52063.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADCK4
Protein Name aarF domain containing kinase 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000315118
InnateDB Gene IDBG-52061 (ADCK4)
Protein Structure
UniProt Annotation
Function May play a role in CoQ10 (COQ10A and/or COQ10B) biosynthesis, which is required for podocyte migration. {ECO:0000269PubMed:24270420}.
Subcellular Localization Mitochondrion membrane {ECO:0000269PubMed:24270420}; Single-pass membrane protein {ECO:0000269PubMed:24270420}. Cytoplasm, cytosol {ECO:0000269PubMed:24270420}. Cell membrane {ECO:0000269PubMed:24270420}.
Disease Associations Nephrotic syndrome 9 (NPHS9) [MIM:615573]: A form of nephrotic syndrome, a renal disease clinically characterized by progressive renal failure, severe proteinuria, hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show focal segmental glomerulosclerosis. {ECO:0000269PubMed:24270420}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Widely expressed, including renal podocytes. {ECO:0000269PubMed:24270420}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004674 protein serine/threonine kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0008152 metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane
Protein Structure and Domains
PDB ID
InterPro IPR004147 UbiB domain
IPR011009 Protein kinase-like domain
PFAM PF03109
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96D53
PhosphoSite PhosphoSite-Q96D53
TrEMBL M0R3F7
UniProt Splice Variant
Entrez Gene 79934
UniGene Hs.720531
RefSeq NP_079152
HUGO HGNC:19041
OMIM 615567
CCDS CCDS12562
HPRD 10632
IMGT
EMBL AC010412 AK022291 BC013114 BC027473
GenPept AAH13114 AAH27473 BAB14004

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca