InnateDB Protein
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IDBP-52065.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ADCK4
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Protein Name
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aarF domain containing kinase 4
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000243583
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InnateDB Gene
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IDBG-52061 (ADCK4)
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Protein Structure
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Function |
May play a role in CoQ10 (COQ10A and/or COQ10B) biosynthesis, which is required for podocyte migration. {ECO:0000269PubMed:24270420}.
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Subcellular Localization |
Mitochondrion membrane {ECO:0000269PubMed:24270420}; Single-pass membrane protein {ECO:0000269PubMed:24270420}. Cytoplasm, cytosol {ECO:0000269PubMed:24270420}. Cell membrane {ECO:0000269PubMed:24270420}.
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Disease Associations |
Nephrotic syndrome 9 (NPHS9) [MIM:615573]: A form of nephrotic syndrome, a renal disease clinically characterized by progressive renal failure, severe proteinuria, hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show focal segmental glomerulosclerosis. {ECO:0000269PubMed:24270420}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Widely expressed, including renal podocytes. {ECO:0000269PubMed:24270420}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0004674
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protein serine/threonine kinase activity
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GO:0016772
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transferase activity, transferring phosphorus-containing groups
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004147
UbiB domain
IPR011009
Protein kinase-like domain
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PFAM |
PF03109
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96D53
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PhosphoSite |
PhosphoSite-Q96D53
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TrEMBL |
M0R340
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UniProt Splice Variant |
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Entrez Gene |
79934
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UniGene |
Hs.720531
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RefSeq |
NP_001136027
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HUGO |
HGNC:19041
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OMIM |
615567
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CCDS |
CCDS46081
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HPRD |
10632
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IMGT |
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EMBL |
AC010412
AK022291
BC013114
BC027473
CH471126
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GenPept |
AAH13114
AAH27473
BAB14004
EAW56988
EAW56989
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