InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HCLS1

Summary

InnateDB Protein

IDBP-52068.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HCLS1

Protein Name

hematopoietic cell-specific Lyn substrate 1

Synonyms

CTTNL; HS1; lckBP1; p75;

Species

Homo sapiens

Ensembl Protein

ENSP00000320176

InnateDB Gene

IDBG-52066 (HCLS1)

Protein Structure

UniProt Annotation

Function

Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.

Subcellular Localization

Membrane {ECO:0000269PubMed:7682714}; Peripheral membrane protein {ECO:0000269PubMed:7682714}. Cytoplasm {ECO:0000269PubMed:7682714}. Mitochondrion {ECO:0000305PubMed:7682714}.

Disease Associations

Tissue Specificity

Expressed only in tissues and cells of hematopoietic origin.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001085	RNA polymerase II transcription factor binding
GO:0003779	actin binding
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0019901	protein kinase binding
GO:0032403	protein complex binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0008284	positive regulation of cell proliferation
GO:0009725	response to hormone
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030041	actin filament polymerization
GO:0030218	erythrocyte differentiation
GO:0030833	regulation of actin filament polymerization
GO:0030854	positive regulation of granulocyte differentiation
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0035556	intracellular signal transduction
GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein
GO:0042993	positive regulation of transcription factor import into nucleus
GO:0045651	positive regulation of macrophage differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051897	positive regulation of protein kinase B signaling
GO:0071345	cellular response to cytokine stimulus
GO:2000107	negative regulation of leukocyte apoptotic process
GO:2000251	positive regulation of actin cytoskeleton reorganization