InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD86

Summary

InnateDB Protein

IDBP-52338.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD86

Protein Name

CD86 molecule

Synonyms

B7-2; B7.2; B70; CD28LG2; LAB72;

Species

Homo sapiens

Ensembl Protein

ENSP00000332049

InnateDB Gene

IDBG-52336 (CD86)

Protein Structure

UniProt Annotation

Function

Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed by activated B-lymphocytes and monocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0015026	coreceptor activity

Biological Process

GO:0001878	response to yeast
GO:0002224	toll-like receptor signaling pathway
GO:0002309	T cell proliferation involved in immune response
GO:0002668	negative regulation of T cell anergy
GO:0006955	immune response
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0007568	aging
GO:0008284	positive regulation of cell proliferation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0016032	viral process
GO:0031295	T cell costimulation
GO:0032496	response to lipopolysaccharide
GO:0034341	response to interferon-gamma
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042102	positive regulation of T cell proliferation
GO:0042104	positive regulation of activated T cell proliferation
GO:0042110	T cell activation
GO:0042113	B cell activation
GO:0042493	response to drug
GO:0043011	myeloid dendritic cell differentiation
GO:0043017	positive regulation of lymphotoxin A biosynthetic process
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045087	innate immune response
GO:0045404	positive regulation of interleukin-4 biosynthetic process
GO:0045630	positive regulation of T-helper 2 cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0051607	defense response to virus
GO:0071222	cellular response to lipopolysaccharide
GO:0071248	cellular response to metal ion
GO:0071345	cellular response to cytokine stimulus

Cellular Component

GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome