InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPINK5

Summary

InnateDB Protein

IDBP-52347.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPINK5

Protein Name

serine peptidase inhibitor, Kazal type 5

Synonyms

LEKTI; LETKI; NETS; NS; VAKTI;

Species

Homo sapiens

Ensembl Protein

ENSP00000256084

InnateDB Gene

IDBG-52343 (SPINK5)

Protein Structure

UniProt Annotation

Function

Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense- activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin. {ECO:0000269PubMed:10419450, ECO:0000269PubMed:17596512, ECO:0000269PubMed:20533828}.

Subcellular Localization

Secreted.

Disease Associations

Netherton syndrome (NETH) [MIM:256500]: An autosomal recessive congenital ichthyosis associated with hair shaft abnormalities and anomalies of the immune system. Typical features are ichthyosis linearis circumflexa, ichthyosiform erythroderma, trichorrhexis invaginata (bamboo hair), atopic dermatitis, and hayfever. High postnatal mortality is due to failure to thrive, infections and hypernatremic dehydration. {ECO:0000269PubMed:10835624}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in the thymus and stratum corneum. Also found in the oral mucosa, parathyroid gland, Bartholin's glands, tonsils, and vaginal epithelium. Very low levels are detected in lung, kidney, and prostate. {ECO:0000269PubMed:10419450}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding

Biological Process

GO:0009913	epidermal cell differentiation
GO:0010951	negative regulation of endopeptidase activity
GO:0016525	negative regulation of angiogenesis
GO:0030198	extracellular matrix organization
GO:0030855	epithelial cell differentiation
GO:0035315	hair cell differentiation
GO:0042640	anagen
GO:0045087	innate immune response (InnateDB)
GO:0045580	regulation of T cell differentiation
GO:0050777	negative regulation of immune response

Cellular Component

GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0005938	cell cortex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0097209	epidermal lamellar body