InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APOO

Summary

InnateDB Protein

IDBP-52481.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APOO

Protein Name

apolipoprotein O

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000368528

InnateDB Gene

IDBG-52479 (APOO)

Protein Structure

UniProt Annotation

Function

Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. May be involved in myocardium-protective mechanisms against lipid accumulation. {ECO:0000269PubMed:16956892}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Secreted {ECO:0000269PubMed:16956892}.

Disease Associations

Tissue Specificity

Expressed in all tissues examined. Up- regulated in diabetic heart. {ECO:0000269PubMed:16956892}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0006869

lipid transport

Cellular Component

GO:0005615	extracellular space
GO:0005739	mitochondrion
GO:0016021	integral component of membrane
GO:0034361	very-low-density lipoprotein particle
GO:0034362	low-density lipoprotein particle
GO:0034364	high-density lipoprotein particle