InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KPNA1

Summary

InnateDB Protein

IDBP-52536.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KPNA1

Protein Name

karyopherin alpha 1 (importin alpha 5)

Synonyms

IPOA5; NPI-1; RCH2; SRP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000343701

InnateDB Gene

IDBG-52534 (KPNA1)

Protein Structure

UniProt Annotation

Function

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:7604027}. Nucleus {ECO:0000269PubMed:7604027}.

Disease Associations

Tissue Specificity

Expressed ubiquitously.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	86 [view]
Protein-Protein	86 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008139	nuclear localization sequence binding
GO:0008565	protein transporter activity

Biological Process

GO:0000018	regulation of DNA recombination
GO:0006309	apoptotic DNA fragmentation
GO:0006606	protein import into nucleus
GO:0006607	NLS-bearing protein import into nucleus
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0016032	viral process
GO:0019058	viral life cycle
GO:0019221	cytokine-mediated signaling pathway
GO:0042307	positive regulation of protein import into nucleus
GO:0045087	innate immune response (InnateDB)
GO:0075733	intracellular transport of virus