InnateDB Protein
|
IDBP-52650.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
DTX3L
|
Protein Name
|
deltex 3-like (Drosophila)
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000373157
|
InnateDB Gene
|
IDBG-52646 (DTX3L)
|
Protein Structure
|
|
Function |
Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post- translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1- dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. {ECO:0000269PubMed:12670957, ECO:0000269PubMed:19818714, ECO:0000269PubMed:23230272}.
|
Subcellular Localization |
Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage in a PARP1-dependent manner.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
40
[view]
|
Protein-Protein |
38
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
1
[view]
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
1 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
|
PFAM |
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q8TDB6
|
PhosphoSite |
PhosphoSite-Q8TDB6
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
151636
|
UniGene |
Hs.708262
|
RefSeq |
|
HUGO |
HGNC:30323
|
OMIM |
613143
|
CCDS |
|
HPRD |
16843
|
IMGT |
|
EMBL |
AF484416
AK125086
AY225123
AY780792
BC042191
BC060509
CH471052
|
GenPept |
AAH42191
AAH60509
AAL90859
AAP57517
AAV98362
BAG54138
EAW79476
|
|
|