InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADRB2

Summary

InnateDB Protein

IDBP-52687.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADRB2

Protein Name

adrenergic, beta-2-, receptor, surface

Synonyms

ADRB2R; ADRBR; B2AR; BAR; BETA2AR;

Species

Homo sapiens

Ensembl Protein

ENSP00000305372

InnateDB Gene

IDBG-52685 (ADRB2)

Protein Structure

UniProt Annotation

Function

Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:19584355}; Multi-pass membrane protein {ECO:0000269PubMed:19584355}. Note=Colocalizes with VHL at the cell membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 336 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	336 [view]
Protein-Protein	335 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004941	beta2-adrenergic receptor activity
GO:0005515	protein binding
GO:0008179	adenylate cyclase binding
GO:0015459	potassium channel regulator activity
GO:0019899	enzyme binding
GO:0042803	protein homodimerization activity
GO:0051380	norepinephrine binding

Biological Process

GO:0001993	regulation of systemic arterial blood pressure by norepinephrine-epinephrine
GO:0002024	diet induced thermogenesis
GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
GO:0002028	regulation of sodium ion transport
GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin
GO:0006898	receptor-mediated endocytosis
GO:0007166	cell surface receptor signaling pathway
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0008333	endosome to lysosome transport
GO:0009409	response to cold
GO:0030501	positive regulation of bone mineralization
GO:0031398	positive regulation of protein ubiquitination
GO:0031649	heat generation
GO:0040015	negative regulation of multicellular organism growth
GO:0042312	regulation of vasodilation
GO:0043410	positive regulation of MAPK cascade
GO:0045087	innate immune response (InnateDB)
GO:0045453	bone resorption
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045986	negative regulation of smooth muscle contraction
GO:0050873	brown fat cell differentiation
GO:0071875	adrenergic receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005764	lysosome
GO:0005768	endosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000332 Beta 2 adrenoceptor
IPR002233 Adrenoceptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00237
PR00562
PR01103

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P07550