Version 5.4
Homo sapiens Protein: FBXO25
Summary
InnateDB Protein IDBP-5276.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXO25
Protein Name F-box protein 25
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000341345
InnateDB Gene IDBG-5270 (FBXO25)
Protein Structure
UniProt Annotation
Function Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000269PubMed:16278047, ECO:0000269PubMed:18287534}. Note=In the nucleus, associates with a subnuclear dot-like structure. Colocalized with SKP1.
Disease Associations Note=A chromosomal aberration involving FBXO25 is a cause of X-linked mental retardation (XLMR). Translocation t(X;8)(p11.22;p23.3) with SHROOM4.
Tissue Specificity Expressed in all brain tissue observed. {ECO:0000269PubMed:16278047}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 194 experimentally validated interaction(s) in this database.
Experimentally validated
Total 194 [view]
Protein-Protein 194 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0019005 SCF ubiquitin ligase complex
Protein Structure and Domains
PDB ID
InterPro IPR001810 F-box domain
PFAM PF00646
PF12937
PF13013
PRINTS
PIRSF
SMART SM00256
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TCJ0
PhosphoSite PhosphoSite-Q8TCJ0
TrEMBL H0YBS4
UniProt Splice Variant
Entrez Gene 26260
UniGene Hs.605765
RefSeq NP_036305
HUGO HGNC:13596
OMIM 609098
CCDS CCDS5954
HPRD 16439
IMGT
EMBL AB070270 AC083964 AF174605 AF419858 BC020249 BC050393
GenPept AAF04526 AAH20249 AAH50393 AAP97293 BAB85128

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca