InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SCYL2

Summary

InnateDB Protein

IDBP-52829.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCYL2

Protein Name

SCY1-like 2 (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000354061

InnateDB Gene

IDBG-52827 (SCYL2)

Protein Structure

UniProt Annotation

Function

Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles. According to PubMed:15809293, probable serine/threonine-protein kinase that phosphorylates, in vitro, the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L- lysine. According to PubMed:16914521, has no detectable kinase activity in vitro. May regulate clathrin-dependent trafficking between the TGN and/or the endosomal system. {ECO:0000269PubMed:15809293, ECO:0000269PubMed:16914521}.

Subcellular Localization

Cytoplasm, perinuclear region. Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus, trans-Golgi network membrane. Endosome membrane. Note=According to PubMed:15809293, plasma membrane-associated in clathrin-coated vesicles. According to PubMed:16914521, colocalizes to the trans- Golgi network (TGN) and to endosomal membranes with clathrin, transferrin and plasma membrane adapter AP1 and AP3 complexes.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0005102	receptor binding
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0002092	positive regulation of receptor internalization
GO:0006468	protein phosphorylation
GO:0008333	endosome to lysosome transport
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2000286	receptor internalization involved in canonical Wnt receptor signaling pathway
GO:2000370	positive regulation of clathrin-mediated endocytosis

Cellular Component

GO:0005794	Golgi apparatus
GO:0010008	endosome membrane
GO:0030136	clathrin-coated vesicle
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR016024 Armadillo-type fold

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt