InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GRPEL2

Summary

InnateDB Protein

IDBP-52871.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRPEL2

Protein Name

GrpE-like 2, mitochondrial (E. coli)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000329558

InnateDB Gene

IDBG-52869 (GRPEL2)

Protein Structure

UniProt Annotation

Function

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000774	adenyl-nucleotide exchange factor activity
GO:0042803	protein homodimerization activity
GO:0051082	unfolded protein binding
GO:0051087	chaperone binding

Biological Process

GO:0006457	protein folding
GO:0006626	protein targeting to mitochondrion
GO:0044267	cellular protein metabolic process
GO:0050790	regulation of catalytic activity