InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CSNK1A1

Summary

InnateDB Protein

IDBP-52969.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSNK1A1

Protein Name

casein kinase 1, alpha 1

Synonyms

CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1; PRO2975;

Species

Homo sapiens

Ensembl Protein

ENSP00000367074

InnateDB Gene

IDBG-52965 (CSNK1A1)

Protein Structure

UniProt Annotation

Function

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. {ECO:0000269PubMed:11955436, ECO:0000269PubMed:1409656, ECO:0000269PubMed:18305108}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus speckle. Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 102 experimentally validated interaction(s) in this database.

Experimentally validated
Total	102 [view]
Protein-Protein	101 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007067	mitotic nuclear division
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0008152	metabolic process
GO:0016055	Wnt signaling pathway

Cellular Component

GO:0000777	condensed chromosome kinetochore
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex
GO:0016020	membrane
GO:0016607	nuclear speck

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt