InnateDB Protein
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IDBP-5304.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TRPM2
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Protein Name
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transient receptor potential cation channel, subfamily M, member 2
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Synonyms
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EREG1; KNP3; LTRPC2; NUDT9H; NUDT9L1; TRPC7;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000300482
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InnateDB Gene
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IDBG-5302 (TRPM2)
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Protein Structure
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Function |
Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity. {ECO:0000269PubMed:11804595}.
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Subcellular Localization |
Membrane {ECO:0000269PubMed:11385575, ECO:0000269PubMed:12594222}; Multi-pass membrane protein {ECO:0000269PubMed:11385575, ECO:0000269PubMed:12594222}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes. {ECO:0000269PubMed:11385575, ECO:0000269PubMed:11509734}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005821
Ion transport domain
IPR015797
NUDIX hydrolase domain-like
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PFAM |
PF00520
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O94759
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PhosphoSite |
PhosphoSite-O94759
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TrEMBL |
C9JZQ8
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UniProt Splice Variant |
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Entrez Gene |
7226
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UniGene |
Hs.369759
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RefSeq |
XP_005261228
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HUGO |
HGNC:12339
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OMIM |
603749
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CCDS |
CCDS13710
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HPRD |
04777
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IMGT |
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EMBL |
AB001535
AB017549
AB166745
AJ417076
AJ878416
AP001063
AP001064
AP001065
AP001754
AY603182
CH471079
DQ012935
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GenPept |
AAT12288
AAY22174
BAA34700
BAA95563
BAB64300
BAD83705
CAD01139
CAI47593
EAX09426
EAX09427
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